180 Degrees works with clients for whom there is significant potential for social innovation, whether due to intensifying problems or emerging possibilities. The two main types of clients are:

1. Small and medium non-profit organizations

180 Degrees assists charitable, educational, health and human service non-profit organisations at the grass-roots level. Many such organisations are suffering from reduced funding and increased demand for their services in light of the global financial crisis, and so benefit from the assistance 180 Degrees provides.

2. Small and medium for-profit organizations with an existing or potential social focus

180 Degrees also works with for-profit organisations who are currently implementing, or who would be willing to consider implementing, socially-oriented business strategies and CSR initiatives. In doing so, 180 Degrees strives to provide small businesses with ways to achieve a social impact without detrimentally affecting their bottom line.